CASE REPORT: SEQUENTIAL COMBINATION TARGETED THERAPY WITH TYPE I AND II MET INHIBITORS IN A METASTATIC EGFR-MUTATED, MET-AMPLIFIED NSCLC PATIENT WITH ACQUIRED MET Y1230H MUTATION

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard of care for advanced non-small-cell lung cancer (NSCLC) patients.However, most patients will eventually develop resistance.For EGFR-TKI resistance mediated by MET amplification, the combination of EGFR and MET TKIs has shown promising results in early clinica

Some snowboarding simulation Nail Polishes methods have been developed.Although snow has unique properties such as granular material and continuum, few snowboard simulation methods can reproduce the discrete behavior of snow.Conventional simulations are unsuitable for reproducing the characteristics of snow when ski and snowboard turns carve throug

Carica papaya is a well-known plant with diverse importance to human beings.The efficacy of microwave-assisted extraction (MAE) in the recovery COLOR REMOVER of phenolic compounds from C.papaya leaf was investigated in this study.The MAE process variables were optimized using response surface method; at the optimized conditions, the embedded phenol

Dug Out Abstract Objective This article seeks to understand the origin of trauma related to the Covid-19 pandemic.Method To achieve this objective, an integrative literature review was conducted, providing a comprehensive, systematic, critical, and reflective analysis.Results The research results reveal that the experience of trauma is unique to ea